Density Functional Theory and Electrochemical Studies: Structure-Efficiency Relationship on Corrosion Inhibition.

The relationship between structure and corrosion inhibition of a series of 30 imidazol, benzimidazol, and pyridine derivatives has been established through the investigation of quantum descriptors calculated with PBE/6-311++G**. A quantitative structure-property relationship model was obtained by examination of these descriptors using a genetic functional approximation method based on a multiple linear regression analysis. Our results indicate that the efficiency of corrosion inhibitors is strongly associated with aromaticity, electron donor ability, and molecular volume descriptors. In order to calibrate and validate the proposed model, we performed electrochemical impedance spectroscopy (EIS) studies on imidazole, 2-methylimidazole, benzimidazole, 2-chloromethylbenzimidazole, pyridine, and 2-aminopyridine compounds. The experimental values for efficiency of corrosion inhibition are in good agreement with the estimated values obtained by our model, thus confirming that our approach represents a promising and suitable tool to predict the inhibition of corrosion attributes of nitrogen containing heterocyclic compounds. The adsorption behavior of imidazole or benzimidazole heterocyclic molecules on the Fe(110) surface was also studied to elucidate the inhibition mechanism; the aromaticity played an important role in the adsorbate-surface complex.

Prevalência de síndrome metabólica em metalúrgicos de diferentes turnos de trabalho / Prevalence of metabolic syndrome in metallurgical workers from different shifts

Objetivo Verificar a prevalência da síndrome metabólica em trabalhadores de diferentes turnos.Métodos A população foi composta por 93 trabalhadores, divididos em: primeiro turno (6h00 às 14h00), segundo turno (14h00 às 22h00), terceiro turno (22h00 às 6h00) e turno produtivo em horário administrativo (7h30 às 17h00). Os componentes da Síndrome Metabólica foram obtidos por meio de coleta de sangue em jejum de 12 horas e medidas antropométricas, pelo critério NCEP-ATP III.Resultados 72% eram do sexo masculino, com idades entre 33 e 38 anos. A síndrome metabólica foi diagnóstica em 26,8% da amostra. A maior prevalência da síndrome ocorreu entre os trabalhadores do primeiro turno (p<0,000). As alterações de HDL-colesterol, glicemia em jejum e triglicérides foram maiores no primeiro turno. Houve diferença para massa corporal, índice de massa corporal e cronótipo (p=0,000), entre os turnos de trabalho.Conclusão A prevalência da síndrome metabólica foi maior nos trabalhadores do primeiro turno.

Objective To investigate the prevalence of metabolic syndrome in workers from different shifts.Methods The population consisted of 93 workers, divided into: first shift (6:00 AM to 2:00 PM), second shift (2:00 PM to 10:00 PM), third shift (10:00 PM to 6:00 AM) and productive shift in administrative hours (7:30 AM to 5:00 PM). The components of the metabolic syndrome were obtained by blood collection in a 12 hour fasting and anthropometric measurements, through the NCEP-ATP III criteria.Results Seventy two percent were male, aged between 33 and 38 years. Metabolic syndrome was diagnosed in 26.8% of the sample. The highest prevalence occurred among first shift workers (p<0.000). The HDL-cholesterol, fasting glucose and triglycerides changes were higher in the first shift. There was difference in body weight, body mass index and chronotype (p=0.000), among working shifts.Conclusion The prevalence of metabolic syndrome was higher among first shift workers.

Astenia en pacientes que asisten a la consulta externa: valoración a través de la escala de intensidad de fatiga (FSS) / Asthenia in patients attending the outpatient clinic: valuation through the rating scale fatigue

Muchos pacientes acuden a consulta externa con un conjunto inespecífico de síntomas y signos que sugieren el diagnóstico de astenia, sin encontrarse una causa orgánica que explique dichos síntomas. Se realizó un estudio prospectivo a nivel nacional para diagnosticar y cuantificar la intensidad de la astenia en estos pacientes y medir la eficacia de la sulbutiamina 400 mg/día como tratamiento farmacológicoa corto plazo de primera línea. Se realizó un estudio abierto, prospectivo y multicéntrico,en el cual se ingresaron 341 pacientes, que consultaron ambulatoriamente y que presentaban síntomas de astenia. A través de la escala de Intensidad de Fatiga (por sus siglas en inglés: Fatigue Severity Scale - FSS) se determinó la presencia de astenia en estos pacientes y se evaluó la eficacia de la sulbutiamina 400 mg/día de Laboratorios Leti S.A.V., Venezuela (Tekron®). El estudio tuvo una duración de 15 días, en los cuales el paciente fue evaluado tres veces: día 1 (inicio), día 7 y día 15. Si el paciente presentaba astenia (puntuación ≥ 36 puntos en la FSS), se le indicaba sulbutiamina400 mg/día con el desayuno por 15 días. El 74,7% de los pacientes evaluados fueron del sexo femenino, con una edad media de 43,7 ± 12,5 años y el 25,3% del sexo masculino con una edad media de 41,7 ± 13,5 años. Al inicio del estudio la media de la puntuación de la FSS fue de 49,7 ± 7,3 puntos; a los 7 días de tratamiento con 400 mg/día de sulbutiamina fue de 37,2 ± 8,8 puntos con una disminucióndel 25,2% y al día 15 fue de 28,0 ± 9,8 puntos con una disminución de 43,7% con respecto al inicio del tratamiento, resultando estadísticamente significativo (p< 0,0001 y p< 0,0001 al día 7 y día 15 vs inicio, respectivamente). El 77,7% de los pacientes respondieron al tratamiento al día 15. La sulbutiamina resultó ser un tratamiento muy bien tolerado, se reportaron eventos adversos leves en 132 pacientes (38,7%) al día 7 y en 115 pacientes(33,7%) al día 15...

Many patients attending out patient clinics with a set of nonspecific symptoms and signs that suggest the diagnosis asthenia, without organic cause to explain the symptoms. In order to determine which of was these patients confirmed the diagnosis of functional asthenia, was performed a prospective nation wide, study to diagnose and quantify the intensity of fatigue in these patients and measure the effectiveness of sulbutiamine 400 mg/day treatment short-term drug frontline. Was realized an open, prospective, multicenter study, which entered 341 outpatient patients which showed signs of fati gue. The Fatigue Severity Scale (FSS) was used as a tool for the diagnosis and evaluation of severity of fatigue and was evaluated the effectiveness of sulbutiamine 400 mg/day to Leti Laboratories, S.A.V. (Tekron®), as first line treatment.The duration of the study was 15 days, with 3 evaluations (day 1 or baseline, day 7 and day 15). The score of the FSS had to be ≥ 36 points to be enrolled. 74,7% of patients were females with a mean age of 43,7 ± 12,5 years old and 25,3% were males with a mean age of 41,7 ± 13,5 years old. At baseline, the FSS score was 49,7 ± 7,3 points; at day 7 was 37,2 ± 8,8 points with a decrease of 25,2% and at day 15 was 28,0 ± 9,8 points, with a decrease of 43,7% respective to baseline, being statistically significant (p< 0,0001 and p< 0,0001 at day 7 and day 15, respectively). The percentage of response to treatment was 77,7% at day 15. Sulbutiamine was a very well tolerated treatment, there were reported mild adverse events in 132 patients (38,7%) at day 7 and in 115 patients (33,7%) at day 15. Sulbutiamine 400 mg/day is a secure treatment, it is well tolerated and effective in improving the asthenia symptoms, as demonstrated in this clinical trial by the significant decrease in the FSS mean score and the percentage of patients with asthenia at day 15 of treatment

Reconstrucción nasal: colgajo nasogeniano: presentación de un caso / Nasal reconstruction: nasolabial flap: introduction of a case

Los colgajos permiten reconstruir defectos restaurando su forma y función. El colgajo nasogeniano tiene características determinadas en cuanto a localización, tamaño, patrón circulatorio, vascularización, inervación y función. Algunas de estas propiedades pueden modificarse. Entre los años 1950-1960, se describen gran número de colgajos regionales de patrón axial, Bakamjian y McGregor desarrollan una importante variedad de colgajos en el área de cabeza y cuello de manera empírica, entre ellos el colgajo nasogeniano. Daniel y Williams confirmaron tres componentes en la vascularización del plexo subdérmico: segmentario, perforantes y vasos directos cutáneos. Millard en 1966, describe las unidades regionales para la nariz; y luego en 1985 Burget y Menick, definieron con detalle estas unidades y sub unidades para la reparación de defectos nasales. Se reporta el caso de un paciente, con antecedente de pérdida de ala nasal derecha, posterior a mordida en una discusión callejera, dando como resultado exposición de la cavidad nasal.

Flaps allow us reconstruct defects restoring nasal shape and function. Nasolabial flaps have certain characteristics regarding location, size, circulatory pattern, vascularization, innervation and function. Some of these properties can be modified. Between 1950 and 1960, a great amount of regional flaps of axial pattern are described. Bakamjian y McGregor develop an important variety of flaps in an empirical way in the area of the head and neck, the nasolabial flap is described among them. Daniel and Williams confirmed three components in the vascularization of the subdermic plexus: segmentary, perforating and direct cutaneous vessels. In 1966 Millard describes the regional units for the nose; and then in 1985 Burget and Menick defined in detail these units and sub units for the repair of nasal defects. The case of a patient is reported. He had a record of right nasal ala loss after a bite in a street fight, resulting in a nasal cavity exposition.